Bosses run from workers starting trouble (10)
I believe the answer is:
management
'bosses' is the definition.
(I have seen 'The bosses' mean 'management' so perhaps 'bosses' could also mean 'management')
'run from workers starting trouble' is the wordplay.
'run' becomes 'manage' (run can mean to manage or be in charge of).
'from' is a charade indicator (letters next to each other).
'workers' becomes 'men' (men can mean staff or employees).
'starting' suggests taking the first letters.
The first letter of 'trouble' is 't'.
'manage'+'men'+'t'='MANAGEMENT'
(Other definitions for management that I've seen before include "Organisation's runners" , "Those in control of an organisation" , "Those running company" , "board" , "Organisation's leaders" .)