Bother, inconvenience (6)
I believe the answer is:
hassle
I believe this clue is a double definition.
'bother' is the first definition.
(synonyms)
'inconvenience' is the second definition.
(I've seen this in another clue)
(Other definitions for hassle that I've seen before include "Colloquial harassment or annoyance" , "Les has (anag) - a great deal of trouble" , "badger" , "problem" , "Modern word for bother and annoyance" .)