Bottle never drunk (5)
I believe the answer is:
nerve
'bottle' is the definition.
(thesaurus)
'never drunk' is the wordplay.
'drunk' is an anagram indicator.
'never' with letters rearranged gives 'NERVE'.
(Other definitions for nerve that I've seen before include "Bodily fibre that communicates sensations" , "Bundle of fibres in the body (5)" , "displaying self-possession" , "Strand of body tissue" , "Fearlessness" .)