Bound to get us wrong again (4)
I believe the answer is:
sure
'bound to' is the definition.
('sure' can be a synonym of 'bound to')
'get us wrong again' is the wordplay.
'get' means one lot of letters go next to another.
'wrong' indicates an anagram.
'again' becomes 're'.
'us' anagrammed gives 'su'.
'su' next to 're' is 'SURE'.
(Other definitions for sure that I've seen before include "stable" , "Completely confident that one is right" , "Agreed" , "Completely certain" , "Safe" .)