Brandy, stuff that's uplifting! (4)
I believe the answer is:
marc
'brandy' is the definition.
(I know that marc is a type of brandy)
'stuff that's uplifting' is the wordplay.
'stuff' becomes 'cram' (synonyms).
'that's uplifting' says the letters should be written in reverse (in a down clue, letters go up).
'cram' in reverse letter order is 'MARC'.
(Other definitions for marc that I've seen before include "Type of brandy" , "Spirit" , "Fruit refuse" , "Brandy distilled from grape residue" , "Grape refuse" .)