Break from female trouble (4)
I believe the answer is:
fail
'break' is the definition.
('fail' can be a synonym of 'break')
'female trouble' is the wordplay.
'female' becomes 'f' (abbreviation).
'trouble' becomes 'ail' ('ail' can be a synonym of 'trouble'**).
'f'+'ail'='FAIL'
'from' is the link.
(Other definitions for fail that I've seen before include "Be unsuccessful, say in exam" , "Fall short" , "Neglect (to do something)" , "Don't succeed" , "Flunk" .)