Break it during a drunken spree (7)
I believe the answer is:
respite
'break' is the definition.
(I've seen this before)
'it during a drunken spree' is the wordplay.
'during' means one lot of letters goes inside another.
'a drunken' indicates an anagram.
'spree' anagrammed gives 'respe'.
'it' placed within 'respe' is 'RESPITE'.
(Other definitions for respite that I've seen before include "Temporary break" , "Period of relief (from unpleasant thing)" , "A lull" , "Pause to rest" , "Abatement, rest" .)