Breakdown out in Iran, unfortunately (9)
I believe the answer is:
ruination
'breakdown' is the definition.
(thesaurus)
'out in iran unfortunately' is the wordplay.
'unfortunately' is an anagram indicator.
'out'+'in'+'iran'='outiniran'
'outiniran' is an anagram of 'RUINATION'.
(Other definitions for ruination that I've seen before include "State of destruction" , "Utter destruction" , "A fruit; Chuck ---, rock 'n' roll singer" , "total disaster" , "Complete destruction or collapse" .)