Brewed ale in UK? That’s different (7)
I believe the answer is:
unalike
'different' is the definition.
(not like something else)
'brewed ale in uk?' is the wordplay.
'brewed' is an anagram indicator.
'ale'+'in'+'uk'='aleinuk'
'aleinuk' with letters rearranged gives 'UNALIKE'.
'that's' acts as a link.
(Other definitions for unalike that I've seen before include "Not similar to one another" , "different" , "Incompatible" , "poor match" , "Dissimilar" .)