Brothel-keeper married first man (5)
I believe the answer is:
madam
'brothel-keeper' is the definition.
I can't tell whether this definition defines the answer.
'married first man' is the wordplay.
'married first' becomes 'm' (ast letter of 'married').
'man' becomes 'adam' (man's name).
'm'+'adam'='MADAM'
Can you help me to learn more?
(Other definitions for madam that I've seen before include "pompous young lady?" , "Leader of House of Congress" , "formidable woman" , "Courteous form of address to a woman" , "Woman of standing" .)