Brushed and organised one’s desk (6)
I believe the answer is:
kissed
'brushed' is the definition.
(kiss can mean to brush against or touch)
'organised one's desk' is the wordplay.
I cannot quite see how this works, but
'one's' could be 'is' (Roman numeral) and 'is' is found in the answer.
an anagram of 'desk' is 'ksed' which is within the remaining letters.
No letters remain.
This may be the basis of clue (or it may be nonsense).
'and' is the link.
(Other definitions for kissed that I've seen before include "Touched lightly" , "Osculated" , "Bussed" , "Touched with lips" , "slightly touched" .)