Bulge in the wall of an artery (8)
I believe the answer is:
aneurysm
(Other definitions for aneurysm that I've seen before include "Permanent abnormal enlargement of an artery" , "Widening of a blood vessel" , "Permanent abnormal dilation of artery" , "Swelling of a blood vessel" , "Sac-like widening of an artery" .)