Burden beginning to worry crew (6)
I believe the answer is:
weight
'burden' is the definition.
(I've seen this before)
'beginning to worry crew' is the wordplay.
'beginning to' indicates taking the first letters.
'crew' becomes 'eight' (I've seen this before).
The initial letter of 'worry' is 'w'.
'w'+'eight'='WEIGHT'
(Other definitions for weight that I've seen before include "Attach importance to" , "Importance, heaviness" , "Trouble" , "Significance" , "Something to lose" .)