Burden of those who stand against us over England (5)
I believe the answer is:
theme
'burden of those who' is the definition.
'theme' can be an answer for 'burden' (synonyms). I am not certain of the remainder of the definition.
'stand against us over england' is the wordplay.
'stand against' becomes 'th' (I can't explain this - if you can you should give a lot more credence to this answer).
'us' becomes 'me' ('us' can mean 'mean' in some UK dialects).
'over' says the letters should be written backwards.
'england' becomes 'E' (short for England).
'me' back-to-front is 'em'.
'th'+'em'+'e'='THEME'
Can you help me to learn more?
(Other definitions for theme that I've seen before include "Topical item" , "idea of the work" , "The main sound" , "issue" , "thing under discussion" .)