Burden on you and me (4)
I believe the answer is:
onus
'burden' is the definition.
('onus' can be a synonym of 'burden')
'on you and me' is the wordplay.
'you and me' becomes 'us'.
'on'+'us'='ONUS'
(Other definitions for onus that I've seen before include "Burden, duty" , "Liability" , "Encumbrance" , "'Burden, load (4)'" , "'Responsibility, task or burden (4)'" .)