Burned out by the responsibility one has to carry (6)
I believe the answer is:
burden
'the responsibility one has to carry' is the definition.
I can't tell whether this definition defines the answer.
'burned out' is the wordplay.
'out' is an anagram indicator (out can mean wrong or inaccurate).
'burned' with letters rearranged gives 'BURDEN'.
'by' acts as a link.
Can you help me to learn more?
(Other definitions for burden that I've seen before include "Unwelcome load" , "Load or responsibility carried" , "A heavy load or difficulty" , "Oppressive duty" , "Main theme (of book)" .)