Bury referee brought up using protein (10)
I believe the answer is:
interferon
'protein' is the definition.
(thesaurus)
'bury referee brought up using' is the wordplay.
'bury' becomes 'inter' (to inter is to put into the ground).
'referee' becomes 'ref' (synonyms).
'brought up' says the letters should be written backwards (in a down clue, letters go up).
'using' becomes 'on' (someone using drugs is 'on' them).
'ref' reversed gives 'fer'.
'inter'+'fer'+'on'='INTERFERON'
(Another definition for interferon that I've seen is " Protein inhibiting virus replication".)