By and large, Oscars host Ellen comes back calm and restful (6)

I believe the answer is:

serene

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'restful' is the definition.
(I've seen this in another clue)

I don't understand the remainder of the clue.

(Other definitions for serene that I've seen before include "Calm and unclouded" , "Calm and composed" , "Peaceful and unruffled" , "Fair" , "Peaceful and contented" .)

I've seen this clue in The Guardian.

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