By the sound of it, travel destination in Italy (4)
I believe the answer is:
rome
'destination in italy' is the definition.
'by the sound of it travel' is the wordplay.
'by the sound of it' shows a homophone (sound like).
'travel' becomes 'roam' (roaming is a kind of travelling).
'roam' sounds like 'ROME'.
(Other definitions for rome that I've seen before include "Capital of Italy" , "church" , "When here, do as the citizens do" , "The Eternal City" , "European capital" .)