Cagney destroyed business (6)
I believe the answer is:
agency
'business' is the definition.
(I know that agency is a type of business)
'cagney destroyed' is the wordplay.
'destroyed' indicates anagramming the letters.
'cagney' is an anagram of 'AGENCY'.
(Other definitions for agency that I've seen before include "Travel ..., advertising..., employment" , "Through which something is accomplished" , "Business that acts for other businesses" , "Administrative unit" , "Recruiters possibly" .)