Calcium put into cosmetic cream for spot (8)
I believe the answer is:
location
'spot' is the definition.
(I've seen this before)
'calcium put into cosmetic cream' is the wordplay.
'calcium' becomes 'Ca' (Ca is the chemical symbol for calcium).
'put into' is an insertion indicator.
'cosmetic cream' becomes 'lotion' (lotion for cosmetic purpose).
'ca' placed into 'lotion' is 'LOCATION'.
'for' acts as a link.
(Other definitions for location that I've seen before include "Particular place" , "Place, position" , "Setting" , "Position,place" , "Position, point in space" .)