Call home in a dreadfully depressed state (11)
I believe the answer is:
melancholia
'depressed state' is the definition.
(I've seen this before)
'call home in a dreadfully' is the wordplay.
'dreadfully' indicates anagramming the letters.
'call'+'home'+'in'+'a'='callhomeina'
'callhomeina' anagrammed gives 'MELANCHOLIA'.
(Other definitions for melancholia that I've seen before include "Black dog" , "Pensive sadness" , "Deep long-lasting sadness" , "Depressed state" , "Feeling of deep sadness" .)