Calmed by medication, James Joyce finally went out (7)
I believe the answer is:
sedated
'calmed by medication' is the definition.
'sedated' can be an answer for 'calmed' ('sedate' can be a synonym of 'calm'). I am not sure about the 'by medication' bit.
'james joyce finally went out' is the wordplay.
'finally' suggests the final letters.
'went out' becomes 'dated' (dating is a kind of going out).
The last letters of 'james joyce' are 'se'.
'se'+'dated'='SEDATED'
Can you help me to learn more?
(Other definitions for sedated that I've seen before include "Drugged" , "Given a tranquilliser" , "Tranquillized" , "Under the influence of drugs" , "Given calming drugs" .)