Can anyone set about creating nuisance? (9)
I believe the answer is:
annoyance
'nuisance?' is the definition.
(thesaurus)
'can anyone set about' is the wordplay.
'set about' is an anagram indicator.
'can'+'anyone'='cananyone'
'cananyone' anagrammed gives 'ANNOYANCE'.
'creating' acts as a link.
(Other definitions for annoyance that I've seen before include "Nuisance" , "Pain" , "Irritation, vexation" , "trouble" , "Source of anger" .)