Cancel and rue heartless toll (6)
I believe the answer is:
repeal
'cancel' is the definition.
(I know that repeal is a more specific form of cancel)
'rue heartless toll' is the wordplay.
'heartless' suggests removing the centre.
'toll' becomes 'peal' (synonyms).
'rue' with its middle taken out is 're'.
're'+'peal'='REPEAL'
'and' is the link.
(Other definitions for repeal that I've seen before include "Abrogate" , "Withdraw law officially" , "Countermand" , "Cancel officially, annul" , "reverse" .)