Canny Katherina perhaps departs (6)
I believe the answer is:
shrewd
'canny' is the definition.
(I've seen this before)
'katherina perhaps departs' is the wordplay.
I cannot really see how this works, but
'departs' could be 'd' (abbreviation used in transport schedules) and 'd' is found within the answer.
The remaining letters 'shrew' is a valid word which might be clued in a way I don't see.
This explanation may well be incorrect...
Can you help me to learn more?
(Other definitions for shrewd that I've seen before include "Sharp-witted" , "sharp" , "worldly wise" , "Wily" , "Clever, having sound judgement" .)