Canoe out of place in a large body of water (5)
I believe the answer is:
ocean
'a large body of water' is the definition.
(I've seen this before)
'canoe out of place' is the wordplay.
'out of place' indicates an anagram.
'canoe' with letters rearranged gives 'OCEAN'.
'in' acts as a link.
(Other definitions for ocean that I've seen before include "Large area of water" , "Pacific, for example" , "The deep" , "Pacific, perhaps" , "Huge sea" .)