Can't move in total refuge (7)
I believe the answer is:
sanctum
'refuge' is the definition.
(I've seen this in another clue)
'can't move in total' is the wordplay.
'move' is an anagram indicator.
'in' indicates putting letters inside.
'total' becomes 'sum' (synonyms).
'cant' with letters rearranged gives 'anct'.
'anct' put within 'sum' is 'SANCTUM'.
(Other definitions for sanctum that I've seen before include "Sacred or safe place" , "A holy place, sometimes inner" , "SECOND PART OF 3" , "Place of total privacy" , "Private place, may be inner" .)