Capital of Turkey change from Moscow’s hardship (7)
I believe the answer is:
trouble
'hardship' is the definition.
(trouble is a kind of hardship)
'capital of turkey change from moscow's' is the wordplay.
'capital of' says to take the initial letters.
'change from moscow' becomes 'rouble' (currency of Russia).
The initial letter of 'turkey' is 't'.
't'+'rouble'='TROUBLE'
(Other definitions for trouble that I've seen before include "Anxiety - disturbance - problem" , "Difficulty, problems" , "Misfortune" , "Disquiet" , "Disturb; difficulty" .)