Capital of Tuscany, Italy (8)
I believe the answer is:
florence
(Other definitions for florence that I've seen before include "Brunelleschi's birthplace" , "Medicis' Tuscan city" , "___ Nightingale, the Lady with the Lamp, d. 1910" , "Len, force yourself to go to Italy" , "Ms Nightingale in great Italian city" .)