Careful handling of fellow, one with throbbing, lacking bit of sense (12)
I believe the answer is:
manipulation
'careful handling' is the definition.
'manipulation' can be an answer for 'handling' (synonyms). I'm unsure of the 'careful' bit.
'of fellow one with throbbing lacking bit of sense' is the wordplay.
I cannot really understand how this works, but
'of' could be 'o' and 'o' is present in the answer.
'fellow' could be 'man' (fellow can mean a man) and 'man' is found within the answer.
'one' could be 'i' (Roman numeral) and 'i' is found within the answer.
'bit' could be 'i' (resembles 1, a binary digit or bit) and 'i' is found in the answer.
This may be the basis of the clue (or it may be nonsense).
Can you help me to learn more?
(Other definitions for manipulation that I've seen before include "Osteopathic technique" , "Osteopath's method" , "Osteopath's technique" , "Artful control" .)