Carry a load of despondency (4)
I believe the answer is:
hump
'carry' is the definition.
(thesaurus)
I don't understand how the rest of the clue works.
Can you help me to learn more?
(Other definitions for hump that I've seen before include "Protuberance; (the) sulks" , "Feature of llama, camel" , "What you get" , "Rounded protuberance" , "sleeping policeman" .)