Cast female lead in drama (4)
I believe the answer is:
shed
'cast' is the definition.
(shedding is a kind of casting)
'female lead in drama' is the wordplay.
'female' becomes 'she' (I've seen this before).
'lead in' suggests taking the first letters.
The first letter of 'drama' is 'd'.
'she'+'d'='SHED'
(Other definitions for shed that I've seen before include "Get rid of -- moult" , "Discarded" , "Lose as trees do leaves" , "something at the bottom of the garden?" , "tools here, maybe?" .)