Castaway off course (6)
I believe the answer is:
crusoe
'castaway' is the definition.
(Robinson Crusoe, from the novel by Daniel Defoe)
'off course' is the wordplay.
'off' indicates anagramming the letters.
'course' with letters rearranged gives 'CRUSOE'.
(Other definitions for crusoe that I've seen before include "5 down [CASTAWAY]" , "Robinson . . . . . . literary castaway" , "See 11" , "Defoe's shipwrecked sailor" , "See 9" .)