Catastrophe as in stride being disrupted (8)
I believe the answer is:
disaster
'catastrophe' is the definition.
(I know that catastrophe can be written as disaster)
'as in stride being disrupted' is the wordplay.
'in' is an insertion indicator.
'being disrupted' indicates anagramming the letters.
'stride' anagrammed gives 'dister'.
'as' put within 'dister' is 'DISASTER'.
(Other definitions for disaster that I've seen before include "Calamity, tragedy" , "Great tradegy or cataclysm" , "Extreme event resulting in great loss and misfortune" , "Sudden catastrophe" , "terrible trouble" .)