Catch terrible cheat causing anguish (9)
I believe the answer is:
heartache
'anguish' is the definition.
(I've seen this before)
'catch terrible cheat' is the wordplay.
'catch' becomes 'hear' (I've seen this before**).
'terrible' is an anagram indicator.
'cheat' with letters rearranged gives 'tache'.
'hear'+'tache'='HEARTACHE'
'causing' acts as a link.
(Other definitions for heartache that I've seen before include "Extreme emotional pain" , "Emotional distress" , "Great sadness" , "expression of sorrow" , "Agony of Love" .)