Catty remark from setter that hurt (4)
I believe the answer is:
meow
'catty remark' is the definition.
(I've seen this in another clue)
'setter that hurt' is the wordplay.
'setter' becomes 'me' (the setter of the clue).
'that hurt' becomes 'ow' (exclamation of pain).
'me'+'ow'='MEOW'
'from' acts as a link.
(Other definitions for meow that I've seen before include "Catty remark" , "Cat's cry" , "Tom's plea for attention" , "reply to spiteful dig" , "Cry of a cat" .)