Cause anger blowing top in joint (5)
I believe the answer is:
ankle
'joint' is the definition.
(ankle is a kind of joint)
'cause anger blowing top' is the wordplay.
'cause anger' becomes 'rankle'.
'blowing top' means to remove the first letter.
'rankle' with its first letter removed is 'ANKLE'.
'in' is the link.
(Other definitions for ankle that I've seen before include "Location of the talus" , "Leg-joint" , "Human joint" , "Major foot joint" , "Foot-leg connector" .)