Cause señora anguish (6)

I believe the answer is:

reason

I'm a little stuck... Click here to teach me more about this clue!

'cause senora anguish' is the definition.
'reason' can be an answer for 'cause' (I've seen this in another clue). I'm not certain of the 'senora anguish' bit.

'cause senora anguish' is the wordplay.
'senora' anagrams to 'REASON'.
Though, I am not sure how the anagram is indicated.

Can you help me to learn more?

(Other definitions for reason that I've seen before include "Logic of senora" , "Cause; mind's power" , "Motive; argue" , "Logic; excuse" , "Justification or motive" .)

I've seen this clue in the Sydney Morning Herald.

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