Cautious with clue far different (7)
I believe the answer is:
careful
'cautious' is the definition.
(synonyms)
'with clue far different' is the wordplay.
'with' is a charade indicator (letters next to each other).
'different' is an anagram indicator (letters placed in a different order).
'clue' put next to 'far' is 'cluefar'.
'cluefar' anagrammed gives 'CAREFUL'.
(Other definitions for careful that I've seen before include "Exercising caution" , "Painstaking" , "Attentive" , "Watch it!" , "'Prudent, cautious (7)'" .)