Certain cadre, unfortunately, locked up (12)
I believe the answer is:
incarcerated
'locked up' is the definition.
(I've seen this before)
'certain cadre unfortunately' is the wordplay.
'unfortunately' indicates an anagram (a bad or unfortunate spelling).
'certain'+'cadre'='certaincadre'
'certaincadre' with letters rearranged gives 'INCARCERATED'.
(Other definitions for incarcerated that I've seen before include "Imprisoned" , "Banged up" , "Locked up" .)