Change course, taking in Tyneside show (6)
I believe the answer is:
veneer
'show' is the definition.
(thesaurus)
'change course taking in tyneside' is the wordplay.
'change course' becomes 'veer' (veer off in a different direction).
'taking in' means one lot of letters goes inside another.
'tyneside' becomes 'NE' (region in North East of England).
'veer' enclosing 'ne' is 'VENEER'.
(Other definitions for veneer that I've seen before include "screen" , "Thin layer of fine wood covering surface of cheaper wood" , "Thin covering on the outside" , "Capital of Kenya" , "Superficial polish" .)