Change direction, skirting one city in Italy (5)
I believe the answer is:
turin
'city in italy' is the definition.
(I've seen this in another clue)
'change direction skirting one' is the wordplay.
'change direction' becomes 'turn' (I've seen this in another clue).
'skirting' is an insertion indicator.
'one' becomes 'i' (Roman numeral).
'turn' placed around 'i' is 'TURIN'.
(Other definitions for turin that I've seen before include "14 Italian city" , "regional capital" , "I turn to the Italian city" , "First capital in 1861 of united Italy" , "Industrial city in northwest Italy" .)