Change of direction from cleric (Irish) (7)
I believe the answer is:
reverse
'change of direction' is the definition.
(reverse is a kind of change of direction)
'cleric irish' is the wordplay.
'cleric' becomes 'rev' (abbreviation for Reverend).
'irish' becomes 'erse' (I've seen this before).
'rev'+'erse'='REVERSE'
'from' acts as a link.
(Other definitions for reverse that I've seen before include "Invert" , "Transpose" , "Setback; go back" , "Move backwards" , "Backtrack" .)