Charles and Edward briefly pursued (6)
I believe the answer is:
chased
'pursued' is the definition.
(synonyms)
'charles and edward briefly' is the wordplay.
'charles' becomes 'Chas' (shortened form).
'and' says to put letters next to each other.
'edward briefly' becomes 'Ed' (short for Edward; 'briefly' indicates a short form).
'chas'+'ed'='CHASED'
(Other definitions for chased that I've seen before include "followed" , "Engraved; rushed" , "Pursued or engraved" , "Pursued at speed" , "Pursued, ran after" .)