Charlie drops out of Middle English course (6)
I believe the answer is:
entree
'course' is the definition.
(course of a meal)
'charlie drops out of middle english' is the wordplay.
'charlie' becomes 'c' (phonetic alphabet: alpha, bravo, charlie etc.).
'drops out of' is a deletion indicator.
'middle' becomes 'centre' (synonyms).
'english' becomes 'e' (abbreviation).
'centre' with 'c' taken away is 'entre'.
'entre'+'e'='ENTREE'
(Other definitions for entree that I've seen before include "Dinner course" , "Main course (or the one before)" , "Main course of a meal" , "Dish allowing one to go in?" , "No way-out" .)