Charlie has synthetic material in drawer? (6)
I believe the answer is:
crayon
'drawer?' is the definition.
(something which draws)
'charlie has synthetic material' is the wordplay.
'charlie' becomes 'C' (phonetic alphabet).
'has' is a charade indicator (letters next to each other).
'synthetic material' becomes 'rayon' (I've seen this before).
'c'+'rayon'='CRAYON'
'in' acts as a link.
(Other definitions for crayon that I've seen before include "drawer" , "Wax colouring stick" , "Stick of coloured wax for drawing (6)" , "Writer" , "Cyrano (anag)" .)