Charm deplorable big leaguer losing rag (7)
I believe the answer is:
beguile
'charm' is the definition.
(synonyms)
'deplorable big leaguer losing rag' is the wordplay.
'deplorable' indicates anagramming the letters.
'losing' is a deletion indicator.
'big'+'leaguer'='bigleaguer'
'bigleaguer' with 'rag' taken out is 'bilegue'.
'bilegue' anagrammed gives 'BEGUILE'.
(Other definitions for beguile that I've seen before include "Charm, win the interest of" , "Charm, enchant" , "Charm or captivate" , "Fascinate" , "Win the attention of, charm" .)