Charm in a hybrid tree, originally (6)
I believe the answer is:
amulet
'charm' is the definition.
(synonyms)
'a hybrid tree originally' is the wordplay.
'hybrid' becomes 'mule' (crossbred from a horse and a donkey).
'originally' suggests taking the first letters.
The initial letter of 'tree' is 't'.
'a'+'mule'+'t'='AMULET'
'in' acts as a link.
(Other definitions for amulet that I've seen before include "Piece of jewelry thought to be a protection against evil" , "Lucky trinket" , "lucky defender" , "Lucky charm, talisman" , "Charm worn to ward off evil" .)