Charming American uplifted by welcome (5)
I believe the answer is:
suave
'charming' is the definition.
(thesaurus)
'american uplifted by welcome' is the wordplay.
'american' becomes 'us'.
'uplifted' says the letters should be written in reverse.
'by' is a charade indicator (letters next to each other).
'welcome' becomes 'ave' (I've seen this before).
'us' in reverse letter order is 'su'.
'su'+'ave'='SUAVE'
(Other definitions for suave that I've seen before include "Urbane and sophisticated" , "Charming, confident" , "Smoothly sophisticated" , "Svelte" , "Debonair" .)